Disorders leading to Autistic-like Symptoms

When you read the research it eventually becomes clear that "autism" is just a bunch of symptoms, rather than a single disease. So autism, as such, has no cure. A specific cause of autistic symptoms in a particular person, may indeed have a remedy, but most sadly do not.

Many causes of autistic symptoms though will have therapies that can reduce and help manage the symptoms. Combine this with the neuroplasticity of the brain and behavioural therapies and a clear way forward emerges.

You will see below that oxidative damage is the main culprit. In the more rare disorders, a genetic mutation is invariably the cause, but even a mosquito can be guilty.

This blog is focused at finding effective therapies for Classic Autism.  In spite of what could be reasonably expected, this is proving very fruitful and genuinely effective therapies actually do exist.

Notes

Oxidative Brain Injury					Comments
	Classic Autism				In utero malformation of cerebellum following oxidative shock.
					Ongoing neuroinflammation. Mixed outcome.
	Regressive Autism				As for classic autism, but with a shock event that triggers inceased inflammation and prompts regression.  Mixed outcome.
	Asperger's				Mild case of classic autism. Prognosis if usually good.
	ADHD				Mild case of classic autism. Prognosis is good.
Neurological Complication of Parasitic Disease
	Cerebral Malaria				Shock inflammation of the cerebellum causes massive damage.
					Treatable if detected early
Unknown
	Childhood disintegrative disorder				Cause unknown, causes complete loss of all skills
					onset between 2 and 10 years old
Genetic mutations/malfunctions
	tuberous sclerosis complex (TSC)				Multi organ genetic disorder
					Rapamycin is used to shrink the tumors.
	Rett Syndrome				Subjects are mainly girls, male fetuses rarely survive.
					Prognosis is often poor.
	Fragile X				Neurodegeneration increases in middle age.
	Phenylketonuria				Treatable if detected early
	Adenylosuccinate lyase deficiency				Viewed as untreatable
	Guanidinoacetate Methyltransferase Deficiency (GAMT)
					Creatine deficiency syndromes
	Arginine: Glycine Amidinotransferase Deficiency (AGAT)				Treatment of oral creatine supplementation can improve
					symptoms, if initiated early, in GAMT and AGAT patients.
					Treatment for CRTR patients, oral creatine supplementation’s
	Creatine Transporter Deficiency (CRTR)				therapeutic effects are limited.
	Smith–Lemli–Opitz Syndrome				inability to produce or synthesize cholesterol due to
					mutation of the DHCR7 gene. Treatable with cholesterol
	Biotinidase deficiency				treatable with biotin
	Infantile Neuronal Ceroid Lipofuscinoses				very rare and fatal
	Sanfilippo syndrome				possible treatment with flavonoid GENISTEIN
	Histidinemia				Rare generally, except in Japan
	Succinic semialdehyde dehydrogenase deficiency (SSADHD)				Defect in ALDH5A1 gene, causes defect in GABA pathway
	Dihydropyrimidine dehydrogenase deficiency (DPD deficiency)				Genetic mutation of DPYD gene