Early on in
this blog I wrote about a supposedly rare condition, where somebody suffers
from sensory overload, usually from sound, but it could be light or even
smell. That condition has fancy sounding
name, Hypokalemic Sensory Overload. The
cure is very simple, just to give oral potassium and within 20 minutes there is
a full recovery. Here is one research study.
In the last
few weeks I received two very thoughtful comments on this blog, from adult
sufferers who have found the same remedy as I have. So at least I am no longer in a minority of
one.
The
interesting thing about potassium in the human body is that it relies on
another electrolyte, magnesium. Without
sufficient magnesium, the body cannot maintain an adequate level of potassium. This is why supplements normally contain both
potassium and magnesium. A problem with
both potassium and magnesium is that they very easily upset the stomach, indeed
some laxatives are based on magnesium.
Epsom salts
I have noted
that the long list of autism interventions used in the US,
frequently includes having a bath in Epsom salts. Epsom salts are named after a town near
London, England, from which they were originally mined. Epsom salts are just magnesium sulphate
(MgSO4).
In the
“biomedical” community it is proposed that magnesium does great things
for autism and/or sulphur does.
The sulphur
part at least has a scientific explanation.
It was long ago shown that there is an apparent abnormality in the sulphur metabolism in autism. In effect there is greater loss than normal of sulphur in the urine, resulting in lower plasma levels than in typical people.
So people
are dipping their kids in Epsom salts on that basis that either the magnesium
or the sulphur will do some good, not sure of which.
Interestingly,
on the web, I found one mother writing about the Epsom salts baths she gives
her child; she says she know when it is time for another one, where her child
starts to cover her ears (sound sensory overload).
Trans-dermal Magnesium
Since
magnesium supplements are in-effect laxatives, other ways have been sought to
administer this electrolyte. There are several
transdermal creams and sprays that do indeed seem to work, but they can irritate the
skin. Interestingly, also on the web,
some autistic adults talk about using such supplements and benefiting.
Making the Connection
Well I hope
this is all obvious to you, at least one of the things that is going on is an ion
channel disease, the result of which is sensory overload in autism. By chance, some people have stumbled upon
magnesium supplementation as a therapy.
The extra magnesium is making whatever potassium there is in that
person’s diet more effective, and hence reducing their symptoms. Since the condition is actually Hypokalemic Sensory Overload, they
would do even better to add some extra potassium as well.
The sulphur
part may, or may not be, a red herring.
Sadly there are many of them in autism.
Conclusion
I have
completed this part of my autism investigation.
If you want to treat autistic sensory overload, that seems to affect almost
all people with ASD and most with ADHD, the options are:-
1. Reduce the body’s daily loss of
potassium and magnesium, with a potassium sparing diuretic, like Spironolactone
2. Increase consumption of potassium and
magnesium in diet. Bananas, oranges and
kiwis are rich in potassium, for example.
3. Use small doses of oral potassium and
magnesium supplements throughout the day
4. Use expensive transdermal magnesium
treatments. Nobody seems to make a
potassium version.
5. Take a soak in the bath with an added
cup of Epsom salts.
There should
be a second reason to try option (1).
For entirely unrelated reasons, this drug is proposed to help in autism
due to its secondary anti-inflammatory and hormonal effects.
Spironolactone might be a desirable immunologic and hormonal intervention in autism spectrum disorders
Spironolactone might be a desirable immunologic and hormonal intervention in autism spectrum disorders
Hi Peter,
ReplyDeleteSo is Sulfur metabolism in ASD abnormal? Rosemary Waring says so but does anybody else? If so, what can be done to ameliorate the effects of abnormal pathways?
As you mention Epsom salts are being tried but Taurine gets a mention as having an anti-opioid effect?
Does taking NAC exert any influence ? Positive or negative with respect to cysteine? How can Taurine help? Is there anything else that can help?
I ask this as restricting our child's selection of food is positively influencing his behaviour and particularly the "opioid-effect" behaviour and the uncontrolled laughter but it's difficult to pin-down.
Regards,
D&G
Nobody seems to have followed up on Rosemary Waring's work. There are many dead-ends in autism research.
DeleteOxidative stress affects numerous processes and is well worth controlling. NAC is used by some cardiologists to lower homocysteine. Betaine is also used many some people with oxidative stress and/or high homocysteine.
Many things appear high/low in autism, but much of this is totally irrelevant. Like the level of metals in hair.
If eating affects your child's behavior you might consider a hypoglycemic diet. It would not help my son, but if eating worsens your son's behavior, it might be related to how he deals with surges in blood glucose levels.
Some people do seem to benefit.
Peter,
ReplyDeleteIs this also related to the need to make high pitch noises. It seems to be a sensory thing or a stim but I am trying to understand where the urge is coming from. I have tried some behavioral tactics but they don’t seem to work.
Anvesh
There’s one more thing, my daughter was being diagnosed with sensory processing disorder, being in the spectrum, PANDAS, OCD.
ReplyDeleteGod revealed to us that we should treat for hookworms ( search on google: hookworms: how a worm gave the south a bad name) there’s a part where it says: one has the impression that the hookworm infection children is living in another, entirely separate world and is only remotely in contact to the everyday world around him) we treated 5 days albendazole, don’t accept pyrantel( it’s not effective) and don’t take it as a no from doctors, hookworms eggs only survive 30 min on a regular fecal exame. On a flotation exame te rate is 54%, this worm is one is the reasons for autism spd etc, after treatment even my daughters personality changed, she is a totally different kid, besides that, now we started with epsom salt baths, taking Lugol, using water filters in the house, and drinking Fiji water that helps reducing aluminum. I’d say: try to get Albendazole from other country since USA is the only that needs prescription and that it costs an eye$$ when you get the pharmacy to order it.