This is a
brief post to pass on some information from Natasa, who reads this blog and has
a big interest in the role of calcium channels in autism.
The readers
of this blog who are doctors express a preference for drugs over supplements,
but for many others the reverse is true.
One problem for the others is how to access prescription only drugs.
Natasa has
pointed out the Olea europaea Leaf Extract (OLE) that is used by
some parents in their “antifungal/antiviral autism protocols”, is actually an
L-type calcium channel blocker.
In Southern Europe Olea europaea leafs are known as a folk remedy for
hypertension (high blood pressure).
ETHNOPHARMACOLOGICAL RELEVANCE:
In
Southern Europe Olea europaea leafs are known as a folk remedy for
hypertension. Cardiovascular diseases are still the leading causes of morbidity
and mortality in industrialized countries with hypertension being one of the
main risk factors.
AIM OF THE STUDY:
We
investigated effects of a commercial Olea europaea leaf extract (OLE) on
isolated hearts and cultured cardiomyocytes.
MATERIALS AND METHODS:
Isolated
rabbit hearts were perfused according to the Langendorff technique and
connected to a 256-channel epicardial mapping system. Voltage clamp experiments
were performed in cultured neonatal rat cardiomyocytes using a perforated-patch
technique.
RESULTS:
OLE
caused a concentration-depended decrease in systolic left ventricular pressure
and heart rate as well as an increase in relative coronary flow and a slight,
but not significant prolongation of PQ-time. There were no significant changes
between the groups in the activation-recovery interval and its dispersion,
total activation time, peak-to-peak amplitude, percentage of identical
breakthrough-points and similar vectors of local activation. Voltage clamp
experiments in cultured neonatal rat cardiomyocytes showed a significant
decrease in maximum I(Ca,L) by OLE which was reversible upon wash-out.
CONCLUSIONS:
OLE suppresses the L-type calcium
channel directly and reversibly. Our findings might help to understand the
traditional use of OLE in the treatment of cardiovascular disease.
Verapamil is
part of my suggested Polypill for classic autism. Several readers of this blog are successfully
using Verapamil, this inexpensive L-type calcium channel blocker.
Many other
readers are unable to access Verapamil.
As many other
parents are already using OLE as a treatment for autism, it would seem
plausible that it is the calcium channel blocking effects that make it
effective. You can search on Google to
see the dosage they use.
Interestingly a randomized controlled double-blind
crossover trial in New Zealand found that olive leaf extract capsules significantly
improved insulin sensitivity and pancreatic β-cell responsiveness in
middle-aged overweight men.
OLE is known
to be an antioxidant, which is another useful property. As we have seen before, antioxidants do
improve insulin sensitivity. We also saw
how Verapamil protected pancreatic β-cells from damage that
leads to type 2 diabetes. This is why
older people on Verapamil, for high blood pressure, tend not to develop type 2
diabetes.
It does look like OLE could have some of the autism benefits
of Verapamil, as well as other properties.
Verapamil is
standardized and extremely cheap, so I will be sticking with that. Olé!
Peter, I am interested in calcium channel blockers and would like to give them a try.
ReplyDeleteHealth sign, a small supplements company offered me three free products of my choice for a trial.
One of them is Panhealth which consists of: Olive leaves extracts 195 mg/tb,
Olive extracts 100 mg/tb and Purica granatum 100 mg/tb all together in a tablet.
How many tablets do you think I should give per day to see results?
I also have a Super antioxidant with numerous things in it, something like Omnium, and a product with broccoli extracts 500 mg together with lycopene 50 mg.
Thank you
Petroula
Olive leaves have numerous properties including lowering cholesterol and lowering blood pressure, the latter is attributed to the effect on calcium channels.
DeleteThe dose of Verapamil that I use is very small (40 to 80 mg divided over the day). This is a very low dose and most people using it to lower blood pressure have far higher doses, Logically the equivalent would be the very lowest dose of olive leaves extract that is suggested for lowering blood pressure.
It may be that your son does not have a calcium channel dysfunction. In responders it has helped reduce aggression, seizures and GI problems.
Hi,
ReplyDeleteI've been giving my son OLE for two years, on and off. It did not seem to have any effect on him. I used it as a part of a typical antiviral/antibacterial protocol. My son does not seem to respond to any treatments. I have ordered verapamil and want to trial it in the nearest future. Do you think it would help, if OLE did not? How long should I try it before giving up?
Polly
This post had caught my attention as we already had some olive leaf extract from when I was attempting to do herbal antibiotics several months ago. My son has been having unexplained tantrums lately out of nowhere. I read much on how Verapamil stops the raging quickly. We are still waiting for our international orders to arrive, so I tried 500 mg olive leaf extract when my son just started getting upset about something. Stopped the tantrum in its tracks. Hope that's a good sign, because I was running out of ideas about what could be making him upset. As someone who highly suspects myself to be Aspergers/level 1 autistic, his meltdowns give me meltdowns, and it's all-around awful. I'll be very happy if this is something we can have figured out.
ReplyDeleteIf it stops the tantrum/meltdown that can only be great news!
DeleteThanks for sharing.
Hello, I haven't written for a long time, I wanted to tell you that we are getting better with Denis, I found something that works very well for his depression and anxiety. We are currently administering 125mg of disulfiram a day, clonazepam 0, 5 twice a day, enterosgel once or twice a day, rifaximin as needed. Difilsuram is the one that got us out of his state of incooperation, the tics are a bit exacerbated but in a different form. We were able to go to the mountains, he endured 5 hours in the car, something unimaginable. His Galagia stopped, he has very few moments when he is vocal, he can stay at home without problems of anger or cooperation, thank you DIFILSURAM for whoever made it, finally a medicine that autism disease (autoimmune encephalitis) does the job for him.
ReplyDeleteI can attest with my trials it helped with anxiety too.
Delete-Stephen